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The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in grown-ups with a body mass index (BMI) of greater than 27, provided they also are afflicted by weight-related health concerns such as Tupe2 diabestes, high cholesterol levels and/or hypertension (blood pressure).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder and as an aid to stopping smoking treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle including a reduced-calorie diet and exercise, Contrave provides another treatment option for chronic weight management for people who are obese or are overweight and still have at least one weight-related health.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated first year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular physical activity. Results from a medical trial that enrolled patients without diabetes showed that patients had a typical weight loss of four.1% rather than participants have been given placebos) after a 12- month period, while another study involving patients with diabetes had a typical weight loss of 2% over treatment with placebo at twelve months.

Using two separate drugs to shed weight can be very effective you can find combinations before the FDA now awaiting approval. When dealing with fat loss and the people who go through it you should err to the side of caution and let the FDA do its job and demand some investigation be done in order that the public recognizes the side effects and dangers of the medications before we bring them. Keep in mind that drug companies will be in business to generate income and that they would say everything to keep people on their medications.

Researchers found out that participants investing in this drug for any year, dropped excess weight within 4 weeks and have kept the body weight off during the entire 56 weeks with the study. Contrave is often a combination with the drugs naltrexone and bupropion, which generally seems to reflect a brand new trend of weight-loss drugs which are made up of more than one active ingredient, which might make them more potent and safer.

Combo-pilling could be the newest fad or even better the newest into the future under scrutiny and thus it is just more publicly known lately, comb-pilling to lose weight has been around since the eighties. The biggest reason that employing a combination of pills is now popular may be the fact that as of right now there aren't any long term prescription diet pills that have been approved by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be approved by the FDA.

Seizures can be a side effect with Contrave and mustn't be taken in those with seizure disorders. The drug also can raise hypertension and pulse rate, and mustn't be used in people with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure and heartbeat and must 't be used in patients with uncontrolled high blood pressure level, along with by a person with heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients having a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients towards the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation.

New UCLA study on smokers with mental, drug, and alcohol problems